![]() Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. There is another brand of denosumab called Xgeva. If a female is inadvertently exposed to denosumab during pregnancy enroll her in the Amgen Pregnancy Surveillance Program (1-80). Prolia should only be used by postmenopausal women. The lowest exposure would be expected during the period of organogenesis. Potential placental transfer of Prolia is dependent upon the IgG subclass and gestational age, generally increasing as pregnancy progresses. Avoid during pregnancy because Prolia may cause fetal harm.When discontinuing Prolia, consider transitioning to another osteoporosis treatment agent. Evaluate the benefits/risks for each patient before starting Prolia. Bone density returns to pretreatment values within 18 months of the last injection of Prolia. The risk decreases to pretreatment values within 24 months. The risk of fracture, including multiple vertebral fractures, increases when Prolia is discontinued, and new vertebral fractures have been reported in as little as 7 months following discontinuation.Prolia must be stored in the refrigerator until needed for use.The grey needle cap that fits onto the end of a pre-filled syringe of Prolia should not be handled by people with latex allergies because it may cause a reaction.Prolia is only available as an injection however, people can be taught how to self-administer Prolia.Prolia may not be suitable for some people including those with low calcium levels (must be corrected before administration), who are pregnant, or with allergic reactions to Prolia or its components. ![]()
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